1. IUPAC nomenclature of organic molecules including regio- and stereoisomers.
2. Principles of stereochemistry: Configurational and conformational isomerism in
acyclic and cyclic compounds; stereogenicity, stereoselectivity, enantioselectivity,
diastereoselectivity and asymmetric induction.
3. Aromaticity: Benzenoid and non-benzenoid compounds – generation and
4. Organic reactive intermediates: Generation, stability and reactivity of
carbocations, carbanions, free radicals, carbenes, benzynes and nitrenes. 5. Organic reaction mechanisms involving addition, elimination and substitution
reactions with electrophilic, nucleophilic or radical species. Determination of
6. Common named reactions and rearrangements – applications in organic synthesis.
7. Organic transformations and reagents: Functional group interconversion including
oxidations and reductions; common catalysts and reagents (organic, inorganic,
organometallic and enzymatic). Chemo, regio and stereoselective transformations.
8. Concepts in organic synthesis: Retrosynthesis, disconnection, synthons, linear and
convergent synthesis, umpolung of reactivity and protecting groups.
9. Asymmetric synthesis: Chiral auxiliaries, methods of asymmetric induction –
substrate, reagent and catalyst controlled reactions; determination of enantiomeric
and diastereomeric excess; enantio-discrimination. Resolution – optical and
10. Pericyclic reactions – electrocyclisation, cycloaddition, sigmatropic
rearrangements and other related concerted reactions. Principles and applications
of photochemical reactions in organic chemistry.
11. Synthesis and reactivity of common heterocyclic compounds containing one or
two heteroatoms (O, N, S).
12. Chemistry of natural products: Carbohydrates, proteins and peptides, fatty acids,
nucleic acids, terpenes, steroids and alkaloids. Biogenesis of terpenoids and
13. Structure determination of organic compounds by IR, UV-Vis, 1H
& 13C NMR
and Mass spectroscopic techniques.
- Teacher: Aji C V