Physical Chemistry - III is a VI th semester UG course

Organic Chemistry 


1. IUPAC nomenclature of organic molecules including regio- and stereoisomers. 


2. Principles of stereochemistry: Configurational and conformational isomerism in 

acyclic and cyclic compounds; stereogenicity, stereoselectivity, enantioselectivity, 

diastereoselectivity and asymmetric induction. 


3. Aromaticity: Benzenoid and non-benzenoid compounds – generation and 



4. Organic reactive intermediates: Generation, stability and reactivity of 

carbocations, carbanions, free radicals, carbenes, benzynes and nitrenes. 5. Organic reaction mechanisms involving addition, elimination and substitution 

reactions with electrophilic, nucleophilic or radical species. Determination of 

reaction pathways. 


6. Common named reactions and rearrangements – applications in organic synthesis. 


7. Organic transformations and reagents: Functional group interconversion including 

oxidations and reductions; common catalysts and reagents (organic, inorganic, 

organometallic and enzymatic). Chemo, regio and stereoselective transformations. 


8. Concepts in organic synthesis: Retrosynthesis, disconnection, synthons, linear and 

convergent synthesis, umpolung of reactivity and protecting groups. 


9. Asymmetric synthesis: Chiral auxiliaries, methods of asymmetric induction – 

substrate, reagent and catalyst controlled reactions; determination of enantiomeric 

and diastereomeric excess; enantio-discrimination. Resolution – optical and 



10. Pericyclic reactions – electrocyclisation, cycloaddition, sigmatropic 

rearrangements and other related concerted reactions. Principles and applications 

of photochemical reactions in organic chemistry


11. Synthesis and reactivity of common heterocyclic compounds containing one or 

two heteroatoms (O, N, S). 


12. Chemistry of natural products: Carbohydrates, proteins and peptides, fatty acids, 

nucleic acids, terpenes, steroids and alkaloids. Biogenesis of terpenoids and 



13. Structure determination of organic compounds by IR, UV-Vis, 1H

 & 13C NMR 

and Mass spectroscopic techniques.